Concise Bible Dictionary:
A declaration of “woe” on man is frequently found in scripture. It is especially pronounced on those who have had privileges and have not answered to them. In the Prophets there are many woes against Israel and Judah, and also against the nations which had to do with Israel. The Lord when on earth pronounced woes upon those who should have been the leaders of His people. The Revelation shows that God’s “woes” will fall with mighty power on those denounced (Rev. 18:13).
Strong’s Dictionary of Hebrew Words:
Meaning:
probably from 183 (in the sense of crying out after); lamentation; also interjectionally Oh!