“Preach the word, be instant in season, out of season; reprove, rebuke, exhort with all long-suffering and doctrine, for the time will come when they will not endure sound doctrine; but after their own lusts shall they heap to themselves teachers, having itching ears; and they shall turn away their ears from the truth, and shall be turned into fables” (2 Tim. 4:2-4).
He is evidently looking to Christians. Timothy was to go on earnestly pressing, because soon they would not listen to him. Whether it were seasonable or not, he was to go on with it, because very soon there would be no season at all.
I do not think the Apostle here means the gospel. The previous chapter speaks of the departure. He is speaking of the evil days. It is not that we are not to be preaching everywhere we can to sinners, but the special thing he has in his mind is that the church would get into such a state that they would not listen to truth. When we preach the gospel now, we preach to people that call themselves Christians. You may meet infidels, it is true. It is of the last days he is speaking. In John’s time they were come in. It was the last time then, though morally developed since. Peter says, “The time is come that judgment will begin at the house of God,” and Jude says that these men “have crept in unawares,” and also that these are they that the Lord comes to judge.
J. N. Darby, Collected Writings, Expository 6