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Genesis 21

Gen. 21:12 KJV (With Strong’s)

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12
And God
'elohiym (Hebrew #430)
gods in the ordinary sense; but specifically used (in the plural thus, especially with the article) of the supreme God; occasionally applied by way of deference to magistrates; and sometimes as a superlative
KJV usage: angels, X exceeding, God (gods)(-dess, -ly), X (very) great, judges, X mighty.
Pronounce: el-o-heem'
Origin: plural of 433
said
'amar (Hebrew #559)
to say (used with great latitude)
KJV usage: answer, appoint, avouch, bid, boast self, call, certify, challenge, charge, + (at the, give) command(-ment), commune, consider, declare, demand, X desire, determine, X expressly, X indeed, X intend, name, X plainly, promise, publish, report, require, say, speak (against, of), X still, X suppose, talk, tell, term, X that is, X think, use (speech), utter, X verily, X yet.
Pronounce: aw-mar'
Origin: a primitive root
unto Abraham
'Abraham (Hebrew #85)
father of a multitude; Abraham, the later name of Abram
KJV usage: Abraham.
Pronounce: ab-raw-hawm'
Origin: contracted from 1 and an unused root (probably meaning to be populous)
, Let it not be grievous
yara` (Hebrew #3415)
properly, to be broken up (with any violent action) i.e. (figuratively) to fear
KJV usage: be grevious (only Isa. 15:4; the rest belong to 7489).
Pronounce: yaw-rah'
Origin: a primitive root
in thy sight
`ayin (Hebrew #5869)
an eye (literally or figuratively); by analogy, a fountain (as the eye of the landscape)
KJV usage: affliction, outward appearance, + before, + think best, colour, conceit, + be content, countenance, + displease, eye((-brow), (-d), -sight), face, + favour, fountain, furrow (from the margin), X him, + humble, knowledge, look, (+ well), X me, open(-ly), + (not) please, presence, + regard, resemblance, sight, X thee, X them, + think, X us, well, X you(-rselves).
Pronounce: ah'-yin
Origin: probably a primitive word
because of the lad
na`ar (Hebrew #5288)
(concretely) a boy (as active), from the age of infancy to adolescence; by implication, a servant; also (by interch. of sex), a girl (of similar latitude in age)
KJV usage: babe, boy, child, damsel (from the margin), lad, servant, young (man).
Pronounce: nah'-ar
Origin: from 5287
, and because of thy bondwoman
'amah (Hebrew #519)
a maid-servant or female slave
KJV usage: (hand-)bondmaid(-woman), maid(-servant).
Pronounce: aw-maw'
Origin: apparently a primitive word
; in all that Sarah
Sarah (Hebrew #8283)
Sarah, Abraham's wife
KJV usage: Sarah.
Pronounce: saw-raw'
Origin: the same as 8282
hath said
'amar (Hebrew #559)
to say (used with great latitude)
KJV usage: answer, appoint, avouch, bid, boast self, call, certify, challenge, charge, + (at the, give) command(-ment), commune, consider, declare, demand, X desire, determine, X expressly, X indeed, X intend, name, X plainly, promise, publish, report, require, say, speak (against, of), X still, X suppose, talk, tell, term, X that is, X think, use (speech), utter, X verily, X yet.
Pronounce: aw-mar'
Origin: a primitive root
unto thee, hearken
shama` (Hebrew #8085)
to hear intelligently (often with implication of attention, obedience, etc.; causatively, to tell, etc.)
KJV usage: X attentively, call (gather) together, X carefully, X certainly, consent, consider, be content, declare, X diligently, discern, give ear, (cause to, let, make to) hear(-ken, tell), X indeed, listen, make (a) noise, (be) obedient, obey, perceive, (make a) proclaim(-ation), publish, regard, report, shew (forth), (make a) sound, X surely, tell, understand, whosoever (heareth), witness.
Pronounce: shaw-mah'
Origin: a primitive root
unto her voice
qowl (Hebrew #6963)
from an unused root meaning to call aloud; a voice or sound
KJV usage: + aloud, bleating, crackling, cry (+ out), fame, lightness, lowing, noise, + hold peace, (pro-)claim, proclamation, + sing, sound, + spark, thunder(-ing), voice, + yell.
Pronounce: kole
Origin: or qol {kole}
; foru in Isaac
Yitschaq (Hebrew #3327)
laughter (i.e. mochery); Jitschak (or Isaac), son of Abraham
KJV usage: Isaac. Compare 3446.
Pronounce: yits-khawk'
Origin: from 6711
shall thy seed
zera` (Hebrew #2233)
seed; figuratively, fruit, plant, sowing-time, posterity
KJV usage: X carnally, child, fruitful, seed(-time), sowing- time.
Pronounce: zeh'-rah
Origin: from 2232
be called
qara' (Hebrew #7121)
to call out to (i.e. properly, address by name, but used in a wide variety of applications)
KJV usage: bewray (self), that are bidden, call (for, forth, self, upon), cry (unto), (be) famous, guest, invite, mention, (give) name, preach, (make) proclaim(- ation), pronounce, publish, read, renowned, say.
Pronounce: kaw-raw'
Origin: a primitive root (rather identical with 7122 through the idea of accosting a person met)
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Cross References

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Ministry on This Verse

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 It was not Ishmael changed, but it was Isaac born. (Genesis 21 by C.H. Mackintosh)
 How truly this was the experience of the Apostle Paul. Christ had the supreme place in his affections, for he could say, “For to me to live is Christ.” The result was that he refused his own righteousness which was of the law, and had no confidence in the flesh (Phil. 1:21; 3:3). He cast out the bondwoman and her son. (The Birth of the Heir: Genesis 21 by H. Smith)
 He was reminded, however, that all blessing was connected with Isaac. To deny oneself and follow Christ will entail a cross—or suffering, but it will lead to great blessing in association with Christ. (The Birth of the Heir: Genesis 21 by H. Smith)

J. N. Darby Translation

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And God said to Abraham, Let it not be grievous in thy sight because of the lad and because of thy handmaid: in all that Sarah hath said to thee hearken to her voice, for in Isaac shall a seed be called to thee.

W. Kelly Translation

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12
And God said unto Abraham, Let it not be grievous in thy sight because of the lad, and because of thy bondwoman; in all that Sarah hath said unto thee, hearken unto her voice; for in Isaac shall thy seed be called.