Col. 4:2 KJV (With Strong’s)

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proskartereo (Greek #4342)
to be earnest towards, i.e. (to a thing) to persevere, be constantly diligent, or (in a place) to attend assiduously all the exercises, or (to a person) to adhere closely to (as a servitor)
KJV usage: attend (give self) continually (upon), continue (in, instant in, with), wait on (continually).
Pronounce: pros-kar-ter-eh'-o
Origin: from 4314 and 2594
i in prayer
ho (Greek #3588)
the definite article; the (sometimes to be supplied, at others omitted, in English idiom)
KJV usage: the, this, that, one, he, she, it, etc.
Pronounce: ho
Origin: ἡ (hay), and the neuter τό (to) in all their inflections
proseuche (Greek #4335)
prayer (worship); by implication, an oratory (chapel)
KJV usage: X pray earnestly, prayer.
Pronounce: pros-yoo-khay'
Origin: from 4336
, and watch
gregoreuo (Greek #1127)
to keep awake, i.e. watch (literally or figuratively)
KJV usage: be vigilant, wake, (be) watch(-ful).
Pronounce: gray-gor-yoo'-o
Origin: from 1453
j in
en (Greek #1722)
"in," at, (up-)on, by, etc.
KJV usage: about, after, against, + almost, X altogether, among, X as, at, before, between, (here-)by (+ all means), for (... sake of), + give self wholly to, (here-)in(-to, -wardly), X mightily, (because) of, (up-)on, (open-)ly, X outwardly, one, X quickly, X shortly, (speedi-)ly, X that, X there(-in, -on), through(-out), (un-)to(-ward), under, when, where(-with), while, with(-in). Often used in compounds, with substantially the same import; rarely with verbs of motion, and then not to indicate direction, except (elliptically) by a separate (and different) preposition.
Pronounce: en
Origin: a primary preposition denoting (fixed) position (in place, time or state), and (by implication) instrumentality (medially or constructively), i.e. a relation of rest (intermediate between 1519 and 1537)
the same
autos (Greek #846)
the reflexive pronoun self, used (alone or in the comparative 1438) of the third person , and (with the proper personal pronoun) of the other persons
KJV usage: her, it(-self), one, the other, (mine) own, said, (self-), the) same, ((him-, my-, thy- )self, (your-)selves, she, that, their(-s), them(-selves), there(-at, - by, -in, -into, -of, -on, -with), they, (these) things, this (man), those, together, very, which. Compare 848.
Pronounce: ow-tos'
Origin: from the particle αὖ (perhaps akin to the base of 109 through the idea of a baffling wind) (backward)
with
en (Greek #1722)
"in," at, (up-)on, by, etc.
KJV usage: about, after, against, + almost, X altogether, among, X as, at, before, between, (here-)by (+ all means), for (... sake of), + give self wholly to, (here-)in(-to, -wardly), X mightily, (because) of, (up-)on, (open-)ly, X outwardly, one, X quickly, X shortly, (speedi-)ly, X that, X there(-in, -on), through(-out), (un-)to(-ward), under, when, where(-with), while, with(-in). Often used in compounds, with substantially the same import; rarely with verbs of motion, and then not to indicate direction, except (elliptically) by a separate (and different) preposition.
Pronounce: en
Origin: a primary preposition denoting (fixed) position (in place, time or state), and (by implication) instrumentality (medially or constructively), i.e. a relation of rest (intermediate between 1519 and 1537)
thanksgiving
eucharistia (Greek #2169)
gratitude; actively, grateful language (to God, as an act of worship)
KJV usage: thankfulness, (giving of) thanks(-giving).
Pronounce: yoo-khar-is-tee'-ah
Origin: from 2170
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Cross References

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Ministry on This Verse

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Continue.
Col. 4:12• 12Epaphras, who is one of you, a servant of Christ, saluteth you, always laboring fervently for you in prayers, that ye may stand perfect and complete in all the will of God. (Col. 4:12)
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Col. 1:9• 9For this cause we also, since the day we heard it, do not cease to pray for you, and to desire that ye might be filled with the knowledge of his will in all wisdom and spiritual understanding; (Col. 1:9)
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1 Sam. 12:23• 23Moreover as for me, God forbid that I should sin against the Lord in ceasing to pray for you: but I will teach you the good and the right way: (1 Sam. 12:23)
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Job 15:4• 4Yea, thou castest off fear, and restrainest prayer before God. (Job 15:4)
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Job 27:8‑10• 8For what is the hope of the hypocrite, though he hath gained, when God taketh away his soul?
9Will God hear his cry when trouble cometh upon him?
10Will he delight himself in the Almighty? will he always call upon God?
(Job 27:8‑10)
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Psa. 55:16‑17• 16As for me, I will call upon God; and the Lord shall save me.
17Evening, and morning, and at noon, will I pray, and cry aloud: and he shall hear my voice.
(Psa. 55:16‑17)
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Psa. 109:4• 4For my love they are my adversaries: but I give myself unto prayer. (Psa. 109:4)
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Luke 18:1• 1And he spake a parable unto them to this end, that men ought always to pray, and not to faint; (Luke 18:1)
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Rom. 12:12• 12Rejoicing in hope; patient in tribulation; continuing instant in prayer; (Rom. 12:12)
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Eph. 6:18• 18Praying always with all prayer and supplication in the Spirit, and watching thereunto with all perseverance and supplication for all saints; (Eph. 6:18)
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Phil. 4:6• 6Be careful for nothing; but in every thing by prayer and supplication with thanksgiving let your requests be made known unto God. (Phil. 4:6)
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1 Thess. 5:17‑18• 17Pray without ceasing.
18In every thing give thanks: for this is the will of God in Christ Jesus concerning you.
(1 Thess. 5:17‑18)
watch.
thanksgiving.
 We are in conflict with evil, which has a hold upon our own hearts if we are without the strength of God. We must therefore commune with God. We must watch therein with settled purpose of heart, not merely as an occasional thing: anyone can cry out when he is in need. (Colossians 4 by J.N. Darby)
 Oftentimes we pray for something but give up….Persevering in prayer does not mean that we are to badger God regarding something we want, and to persist in asking for it until He gives it to us. (Christ Expressed in the Spread of the Truth in the World by B. Anstey)
 To “watch in the same” is to watch for the Lord’s answer to our prayer requests. This manifests faith. To do it “with thanksgiving” manifests confidence in the Lord. It is to say, “Whatever the Lord gives as an answer (be it ‘yes’ or ‘no’), I know that it will be the best for me. (Christ Expressed in the Spread of the Truth in the World by B. Anstey)
 Neither completeness in Christ, nor joyful sense of heavenly relationship, nor heed to our own relations in this life, should weaken for an instant, but rather minister to an increased sense of the need and value of depending on God. (Colossians 4 by W. Kelly)

J. N. Darby Translation

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Persevere in prayer, watching in it with thanksgiving;

W. Kelly Translation

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Persevere in prayer, watching in it with thanksgiving;