Gen. 21:18 KJV (With Strong’s)

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18
Arise
quwm (Hebrew #6965)
to rise (in various applications, literal, figurative, intensive and causative)
KJV usage: abide, accomplish, X be clearer, confirm, continue, decree, X be dim, endure, X enemy, enjoin, get up, make good, help, hold, (help to) lift up (again), make, X but newly, ordain, perform, pitch, raise (up), rear (up), remain, (a-)rise (up) (again, against), rouse up, set (up), (e-)stablish, (make to) stand (up), stir up, strengthen, succeed, (as-, make) sure(-ly), (be) up(-hold, - rising).
Pronounce: koom
Origin: a primitive root
, lift up
nasa' (Hebrew #5375)
a primitive root; to lift, in a great variety of applications, literal and figurative, absol. and rel. (as follows)
KJV usage: accept, advance, arise, (able to, (armor), suffer to) bear(-er, up), bring (forth), burn, carry (away), cast, contain, desire, ease, exact, exalt (self), extol, fetch, forgive, furnish, further, give, go on, help, high, hold up, honorable (+ man), lade, lay, lift (self) up, lofty, marry, magnify, X needs, obtain, pardon, raise (up), receive, regard, respect, set (up), spare, stir up, + swear, take (away, up), X utterly, wear, yield.
Pronounce: naw-saw'
Origin: or nacah (Psalm 4 : 6 (7)) {naw-saw'}
the lad
na`ar (Hebrew #5288)
(concretely) a boy (as active), from the age of infancy to adolescence; by implication, a servant; also (by interch. of sex), a girl (of similar latitude in age)
KJV usage: babe, boy, child, damsel (from the margin), lad, servant, young (man).
Pronounce: nah'-ar
Origin: from 5287
, and hold
chazaq (Hebrew #2388)
to fasten upon; hence, to seize, be strong (figuratively, courageous, causatively strengthen, cure, help, repair, fortify), obstinate; to bind, restrain, conquer
KJV usage: aid, amend, X calker, catch, cleave, confirm, be constant, constrain, continue, be of good (take) courage(-ous, -ly), encourage (self), be established, fasten, force, fortify, make hard, harden, help, (lay) hold (fast), lean, maintain, play the man, mend, become (wax) mighty, prevail, be recovered, repair, retain, seize, be (wax) sore, strengthen (self), be stout, be (make, shew, wax) strong(-er), be sure, take (hold), be urgent, behave self valiantly, withstand.
Pronounce: khaw-zak'
Origin: a primitive root
him in thine hand
yad (Hebrew #3027)
a hand (the open one (indicating power, means, direction, etc.), in distinction from 3709, the closed one); used (as noun, adverb, etc.) in a great variety of applications, both literally and figuratively, both proximate and remote (as follows)
KJV usage: (+ be) able, X about, + armholes, at, axletree, because of, beside, border, X bounty, + broad, (broken-)handed, X by, charge, coast, + consecrate, + creditor, custody, debt, dominion, X enough, + fellowship, force, X from, hand(-staves, -y work), X he, himself, X in, labour, + large, ledge, (left-)handed, means, X mine, ministry, near, X of, X order, ordinance, X our, parts, pain, power, X presumptuously, service, side, sore, state, stay, draw with strength, stroke, + swear, terror, X thee, X by them, X themselves, X thine own, X thou, through, X throwing, + thumb, times, X to, X under, X us, X wait on, (way-)side, where, + wide, X with (him, me, you), work, + yield, X yourselves.
Pronounce: yawd
Origin: a primitive word
; forb I will make
suwm (Hebrew #7760)
a primitive root; to put (used in a great variety of applications, literal, figurative, inferentially, and elliptically)
KJV usage: X any wise, appoint, bring, call (a name), care, cast in, change, charge, commit, consider, convey, determine, + disguise, dispose, do, get, give, heap up, hold, impute, lay (down, up), leave, look, make (out), mark, + name, X on, ordain, order, + paint, place, preserve, purpose, put (on), + regard, rehearse, reward, (cause to) set (on, up), shew, + stedfastly, take, X tell, + tread down, ((over-))turn, X wholly, work.
Pronounce: soom
Origin: or siym {seem}
him a great
gadowl (Hebrew #1419)
from 1431; great (in any sense); hence, older; also insolent
KJV usage: + aloud, elder(-est), + exceeding(-ly), + far, (man of) great (man, matter, thing,-er,-ness), high, long, loud, mighty, more, much, noble, proud thing, X sore, (X ) very.
Pronounce: gaw-dole'
Origin: or (shortened) gadol {gaw-dole'}
nation
gowy (Hebrew #1471)
apparently from the same root as 1465 (in the sense of massing); a foreign nation; hence, a Gentile; also (figuratively) a troop of animals, or a flight of locusts
KJV usage: Gentile, heathen, nation, people.
Pronounce: go'-ee
Origin: rarely (shortened) goy {go'-ee}
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Cross References

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Ministry on This Verse

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I will.
Gen. 21:13• 13And also of the son of the bondwoman will I make a nation, because he is thy seed. (Gen. 21:13)
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Gen. 16:10• 10And the angel of the Lord said unto her, I will multiply thy seed exceedingly, that it shall not be numbered for multitude. (Gen. 16:10)
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Gen. 17:20• 20And as for Ishmael, I have heard thee: Behold, I have blessed him, and will make him fruitful, and will multiply him exceedingly; twelve princes shall he beget, and I will make him a great nation. (Gen. 17:20)
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Gen. 25:12‑18• 12Now these are the generations of Ishmael, Abraham's son, whom Hagar the Egyptian, Sarah's handmaid, bare unto Abraham:
13And these are the names of the sons of Ishmael, by their names, according to their generations: the firstborn of Ishmael, Nebajoth; and Kedar, and Adbeel, and Mibsam,
14And Mishma, and Dumah, and Massa,
15Hadar, and Tema, Jetur, Naphish, and Kedemah:
16These are the sons of Ishmael, and these are their names, by their towns, and by their castles; twelve princes according to their nations.
17And these are the years of the life of Ishmael, an hundred and thirty and seven years: and he gave up the ghost and died; and was gathered unto his people.
18And they dwelt from Havilah unto Shur, that is before Egypt, as thou goest toward Assyria: and he died in the presence of all his brethren.
(Gen. 25:12‑18)
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1 Chron. 1:29‑31• 29These are their generations: The firstborn of Ishmael, Nebaioth; then Kedar, and Adbeel, and Mibsam,
30Mishma, and Dumah, Massa, Hadad, and Tema,
31Jetur, Naphish, and Kedemah. These are the sons of Ishmael.
(1 Chron. 1:29‑31)
 Historically he is preserved according to God’s promise, a figure of legal Israel; but, as regards any portion of the inheritance, wholly cast out. (Genesis 20-21 by J.N. Darby)

J. N. Darby Translation

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18
Arise, take the lad, and hold him in thy hand; for I will make of him a great nation.