Gen. 21:18 KJV (With Strong’s)

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18
Arise
quwm (Hebrew #6965)
to rise (in various applications, literal, figurative, intensive and causative)
KJV usage: abide, accomplish, X be clearer, confirm, continue, decree, X be dim, endure, X enemy, enjoin, get up, make good, help, hold, (help to) lift up (again), make, X but newly, ordain, perform, pitch, raise (up), rear (up), remain, (a-)rise (up) (again, against), rouse up, set (up), (e-)stablish, (make to) stand (up), stir up, strengthen, succeed, (as-, make) sure(-ly), (be) up(-hold, - rising).
Pronounce: koom
Origin: a primitive root
, lift up
nasa' (Hebrew #5375)
a primitive root; to lift, in a great variety of applications, literal and figurative, absol. and rel. (as follows)
KJV usage: accept, advance, arise, (able to, (armor), suffer to) bear(-er, up), bring (forth), burn, carry (away), cast, contain, desire, ease, exact, exalt (self), extol, fetch, forgive, furnish, further, give, go on, help, high, hold up, honorable (+ man), lade, lay, lift (self) up, lofty, marry, magnify, X needs, obtain, pardon, raise (up), receive, regard, respect, set (up), spare, stir up, + swear, take (away, up), X utterly, wear, yield.
Pronounce: naw-saw'
Origin: or nacah (Psalm 4 : 6 (7)) {naw-saw'}
the lad
na`ar (Hebrew #5288)
(concretely) a boy (as active), from the age of infancy to adolescence; by implication, a servant; also (by interch. of sex), a girl (of similar latitude in age)
KJV usage: babe, boy, child, damsel (from the margin), lad, servant, young (man).
Pronounce: nah'-ar
Origin: from 5287
, and hold
chazaq (Hebrew #2388)
to fasten upon; hence, to seize, be strong (figuratively, courageous, causatively strengthen, cure, help, repair, fortify), obstinate; to bind, restrain, conquer
KJV usage: aid, amend, X calker, catch, cleave, confirm, be constant, constrain, continue, be of good (take) courage(-ous, -ly), encourage (self), be established, fasten, force, fortify, make hard, harden, help, (lay) hold (fast), lean, maintain, play the man, mend, become (wax) mighty, prevail, be recovered, repair, retain, seize, be (wax) sore, strengthen (self), be stout, be (make, shew, wax) strong(-er), be sure, take (hold), be urgent, behave self valiantly, withstand.
Pronounce: khaw-zak'
Origin: a primitive root
him in thine hand
yad (Hebrew #3027)
a hand (the open one (indicating power, means, direction, etc.), in distinction from 3709, the closed one); used (as noun, adverb, etc.) in a great variety of applications, both literally and figuratively, both proximate and remote (as follows)
KJV usage: (+ be) able, X about, + armholes, at, axletree, because of, beside, border, X bounty, + broad, (broken-)handed, X by, charge, coast, + consecrate, + creditor, custody, debt, dominion, X enough, + fellowship, force, X from, hand(-staves, -y work), X he, himself, X in, labour, + large, ledge, (left-)handed, means, X mine, ministry, near, X of, X order, ordinance, X our, parts, pain, power, X presumptuously, service, side, sore, state, stay, draw with strength, stroke, + swear, terror, X thee, X by them, X themselves, X thine own, X thou, through, X throwing, + thumb, times, X to, X under, X us, X wait on, (way-)side, where, + wide, X with (him, me, you), work, + yield, X yourselves.
Pronounce: yawd
Origin: a primitive word
; forb I will make
suwm (Hebrew #7760)
a primitive root; to put (used in a great variety of applications, literal, figurative, inferentially, and elliptically)
KJV usage: X any wise, appoint, bring, call (a name), care, cast in, change, charge, commit, consider, convey, determine, + disguise, dispose, do, get, give, heap up, hold, impute, lay (down, up), leave, look, make (out), mark, + name, X on, ordain, order, + paint, place, preserve, purpose, put (on), + regard, rehearse, reward, (cause to) set (on, up), shew, + stedfastly, take, X tell, + tread down, ((over-))turn, X wholly, work.
Pronounce: soom
Origin: or siym {seem}
him a great
gadowl (Hebrew #1419)
from 1431; great (in any sense); hence, older; also insolent
KJV usage: + aloud, elder(-est), + exceeding(-ly), + far, (man of) great (man, matter, thing,-er,-ness), high, long, loud, mighty, more, much, noble, proud thing, X sore, (X ) very.
Pronounce: gaw-dole'
Origin: or (shortened) gadol {gaw-dole'}
nation
gowy (Hebrew #1471)
apparently from the same root as 1465 (in the sense of massing); a foreign nation; hence, a Gentile; also (figuratively) a troop of animals, or a flight of locusts
KJV usage: Gentile, heathen, nation, people.
Pronounce: go'-ee
Origin: rarely (shortened) goy {go'-ee}
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Cross References

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Ministry on This Verse

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I will.
Gen. 21:13• 13But also the son of the handmaid will I make a nation, because he is thy seed. (Gen. 21:13)
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Gen. 16:10• 10And the Angel of Jehovah said to her, I will multiply thy seed exceedingly, that it shall not be numbered for multitude. (Gen. 16:10)
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Gen. 17:20• 20And for Ishmael I have heard thee: behold, I will bless him, and will make him fruitful, and will very greatly multiply him; twelve princes shall he beget, and I will make him a great nation. (Gen. 17:20)
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Gen. 25:12‑18• 12And these are the generations of Ishmael, Abraham's son, whom Hagar the Egyptian, Sarah's bondwoman, bore to Abraham.
13And these are the names of the sons of Ishmael by their names according to their generations: Nebaioth, the firstborn of Ishmael; and Kedar, and Adbeel, and Mibsam,
14and Mishma, and Dumah, and Massa,
15Hadad and Tema, Jetur, Naphish and Kedmah.
16These are the sons of Ishmael, and these are their names, in their hamlets and their encampments--twelve princes of their peoples.
17And these are the years of the life of Ishmael: a hundred and thirty-seven years; and he expired and died, and was gathered to his peoples.
18And they dwelt from Havilah to Shur, which is opposite to Egypt, as one goes towards Assyria. He settled before the face of all his brethren.
(Gen. 25:12‑18)
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1 Chron. 1:29‑31• 29These are their generations: the firstborn of Ishmael, Nebaioth; and Kedar, and Adbeel, and Mibsam;
30Mishma and Dumah; Massa, Hadad, and Tema;
31Jetur, Naphish, and Kedmah: those are the sons of Ishmael.
(1 Chron. 1:29‑31)
 Historically he is preserved according to God’s promise, a figure of legal Israel; but, as regards any portion of the inheritance, wholly cast out. (Genesis 20-21 by J.N. Darby)

J. N. Darby Translation

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18
Arise, take the lad, and hold him in thy hand; for I will make of him a great nation.