V.1-7 When Jesus was on earth, He was the true vine. Israel should have been this vine (Psa. 80:88Thou hast brought a vine out of Egypt: thou hast cast out the heathen, and planted it. (Psalm 80:8)). The branches must abide in the vine or they could not bear any fruit. If a man did not abide in Him, he was cast out as a dried branch, because he was merely a professor. These verses are saying that without Him we can do nothing (v. 5). Many people think they are Christians, because they live a good clean life; but the Lord Jesus has no power over their life — they are not born again.
V.8-11 These verses have been called the royal road to happiness. Are they true of us? We receive fullness of joy through obedience (v. 11).
V.18-27 The world hates a believer in the Lord Jesus, who is living for Him.
V.24-25 If they had not had the miracles which He did, there might have been an excuse for their not believing in Him, but now they have no excuse.